New JEOL NMR Probe Developed for Fluorinated Compounds in Pharma

New JEOL NMR Probe for Fluorinated Compounds

With the introduction of the ROYAL HFX probe for Nuclear  Magnetic Resonance (NMR) Spectroscopy, JEOL offers a new level of flexibility for NMR analysis of fluorinated compounds prevalent in many new pharmaceutical products.

The ROYAL HFX is the world’s first liquid NMR probe with the capability to automatically switch between single tune and dual tune modes on the high frequency coil without compromising single tune performance. The probe can be used with routine 2-channel spectrometers or with 3-channel systems for expanded capabilities.

Operating in single tune mode, the patent pending JEOL ROYAL HFX probe has the same high performance for sensitivity and pulse widths as the current standard JEOL ROYAL NMR probe. Operating the HFX probe in dual tune mode allows for a wide variety of advanced 1H and 19F NMR experiments including 1H{19F}, 19F{1H}, 13C{1H,19F}, X{1H,19F}, and many unique 13C{1H,19F}, or X{1H, 19F} correlation experiments to simplify spectral assignments of modern complex fluorine containing compounds for the pharmaceutical and polymer industries. The Low Frequency X coil is not limited to 13C, but can be tuned to any nucleus between 31P and 15N with the same experimental flexibility as 13C experiments; a feature unique to the JEOL Royal HFX NMR Probe.

For more than 50 years, JEOL has been known for its NMR expertise and support. The new generation of JEOL ECZ NMR systems feature compact spectrometers and space-saving actively-shielded magnets. The JEOL ECZ series NMR recently received the “Good Design Award 2016” in Japan from the Japan Institute of Design Promotion. Models range from an entry-level NMR Spectrometer at 400 MHz to expandable, high performance research grade NMR Spectrometers from  400 MHz to as high as 1.2 GHz. JEOL offers a wide variety of NMR probes and continues to develop new probe technology for its state-of-the-art NMR product line.


JEOL is a world leader in electron optical equipment and instrumentation for high-end scientific and industrial research and development. Core product groups include electron microscopes (SEMs and TEMs), instruments for the semiconductor industry (electron beam lithography and a series of defect review and inspection tools), and analytical instruments including mass spectrometers, NMRs and ESRs.

JEOL USA, Inc., a wholly owned subsidiary of JEOL, Ltd., Japan, was incorporated in the United States in 1962.  The company has 13 regional service centers that offer unlimited emergency service and support in the U.S.

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